Improved Ion Mobility Separation of Protein Conformations in the Gas Phase with SYNAPT G2 HDMS
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چکیده
Methods for determining changes in higher order structure are valuable to stability studies and purification development, especially those that can be implemented in a high throughput manner. It is often time-consuming to separate or identify different conformations. Recent work on hydrogen-deuterium (HD) exchange shows how ion mobility separation (IMS) can be used to differentiate conformations of heterogeneous biomolecules such as IgG.1
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تاریخ انتشار 2010